An improved synthesis of 1,2,4-triazoles using Ag2CO3

被引：84

作者：

Paulvannan, K ^{[1
]}

Chen, T ^{[1
]}

Hale, R ^{[1
]}

机构：

[1] Affymax Res Inst, Santa Clara, CA 95051 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 41期

关键词：

hydrazone; nitrilimines; cycloaddition; triazoles;

D O I：

10.1016/S0040-4020(00)00726-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved synthesis of 1,3,5-trisubstituted 1,2,4-triazoles via Ag2CO3 mediated cyclization of triazenes has been developed. This approach is flexible and compatible with a wide range of functional groups. The reaction was complete within 3 h and the products were isolated in moderate to high yields. The influence of the beta-substituents of the amines on the triazole formation was also studied. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8071 / 8076

页数：6

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