Down-Regulation of the Escherichia coli K-12 nrf Promoter by Binding of the NsrR Nitric Oxide-Sensing Transcription Repressor to an Upstream Site

被引：17

作者：

Browning, Douglas F. ^{[1
]}

Lee, David J. ^{[1
]}

Spiro, Stephen ^{[2
]}

Busby, Stephen J. W. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] Univ Texas Dallas, Dept Mol & Cell Biol, Richardson, TX 75080 USA

来源：

JOURNAL OF BACTERIOLOGY | 2010年 / 192卷 / 14期

基金：

英国惠康基金; 美国国家科学基金会;

关键词：

DEPENDENT TRANSCRIPTION; REDUCTASE; PROTEIN; ACTIVATION; SEQUENCE; NITRATE; OPERON; GENE; NARL; FIS;

D O I：

10.1128/JB.00218-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

FNR-dependent activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF, which bind to overlapping targets adjacent to the DNA site for FNR. The NsrR target is inactivated by mutation at the Salmonella enterica serovar Typhimurium nrf promoter.

引用

页码：3824 / 3828

页数：5

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