Dual effect of synthetic aminoglycosides:: Antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

被引：68

作者：

Fridman, M

Belakhov, V

Lee, LV

Liang, FS

Wong, CH

Baasov, T

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

[4] Technion Israel Inst Technol, Inst Catalysis Sci & Technol, IL-32000 Haifa, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期

关键词：

aminoglycosides; anthrax; antibiotics; inhibitors;

D O I：

10.1002/anie.200462003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis. (Chemical Equation Presented).

引用

收藏

页码：447 / 452

页数：6

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