Diarylprolinol Silyl Ether Salts as New, Efficient, Water-Soluble, and Recyclable Organocatalysts for the Asymmetric Michael Addition on Water

被引：195

作者：

Zheng, Zilong ^{[1
]}

Perkins, Benjamin L. ^{[1
]}

Ni, Bukuo ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, Commerce, TX 75429 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 01期

基金：

美国国家科学基金会;

关键词：

CONJUGATE ADDITION; ACID CATALYSTS; ALDEHYDES; KETONES; NITROOLEFINS; NITROALKENES;

D O I：

10.1021/ja9093583

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel strategy for the catalytic asymmetric Michael addition of aldehydes to nitroolefins on water has been developed and provided the Michael adducts in excellent diastereo- and enantioselectivities. A notable feature of these organocatalysts is that they can be recycled for more than six times without a significant loss of catalytic activity and stereochemical control. In addition, the synthetic procedure presented is simple, practical, and environmentally benign.

引用

页码：50 / +

页数：4

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