Dual Stimuli-Responsive Supramolecular Polypeptide-Based Hydrogel and Reverse Micellar Hydrogel Mediated by Host-Guest Chemistry

被引:186
作者
Chen, Yi [1 ]
Pang, Xiao-Hui [1 ]
Dong, Chang-Ming [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Shanghai 200240, Peoples R China
基金
中国国家自然科学基金;
关键词
SOL-GEL TRANSITION; DRUG-DELIVERY; DIBLOCK COPOLYMER; CLICK CHEMISTRY; CYCLODEXTRIN; POLYMERS; BEHAVIOR; RECOGNITION; BIOHYBRIDS; RELEASE;
D O I
10.1002/adfm.200901400
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Versatile strategies are currently being discovered for the fabrication of synthetic polypeptide-based hybrid hydrogels, which have potential applications in polymer therapeutics and regenerative medicine. Herein, a new concept-the reverse micellar hydrogel-is introduced, and a versatile strategy is provided for fabricating supramolecular polypeptide-based normal micellar hydrogel and reverse micellar hydrogels from the same polypeptide-based copolymer via the cooperation of host-guest chemistry and hydrogen-bonding interactions. The supramolecular hydrogels are thoroughly characterized, and a mechanism for their self-assembly is proposed. These hydrogels can respond to dual stimuli-temperature and pH-and their mechanical and controlled drug-release properties can be tuned by the copolymer topology and the polypeptide composition. The reverse micellar hydrogel can load 10% of the anticancer drug doxorubicin hydrochloride (DOX) and sustain DOX release for 45 days, indicating that it could be useful as an injectable drug delivery system.
引用
收藏
页码:579 / 586
页数:8
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