Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection

被引：34

作者：

Boldrini, V

Giovenzana, GB

Pagliarin, R

Palmisano, G

Sisti, M

机构：

[1] Dipartimento Sci Chim Fis & Matemat, I-22100 Como, Italy

[2] Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[3] Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)01092-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of cyclen 1 with chloral hydrate afforded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups provided a selective entry into N-monosubstituted cyclen derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6527 / 6530

页数：4

共 18 条

[1] Lanthanide(III) chelates for NMR biomedical applications [J].