Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms

被引:27
作者
Chadi, G
Fuxe, K
机构
[1] Univ Sao Paulo, ICB, Dept Anat, Lab Fatores Neurotrof & Plasticidade Neuronal, BR-05508900 Sao Paulo, Brazil
[2] Karolinska Inst, Dept Neurosci, Div Cellular & Mol Neurochem, Stockholm, Sweden
关键词
radioautography; in situ hybridization; basic fibroblast growth factor; FGF receptor; astrocyte; image analysis; central nervous system; brain lesion;
D O I
10.1590/S0100-879X1998000200007
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The actions of fibroblast growth factors (FGFs), particularly the basic form (bFGF), have been described in a large number of cells and include mitogenicity, angiogenicity and wound repair. The present review discusses the presence of the bFGF protein and messenger RNA as well as the presence of the FGF receptor messenger RNA in the rodent brain by means of semiquantitative radioactive in situ hybridization in combination with immunohistochemistry. Chemical and mechanical injuries to the brain trigger a reduction in neurotransmitter synthesis and neuronal death which are accompanied by astroglial reaction. The altered synthesis of bFGF following brain lesions or stimulation was analyzed. Lesions of the central nervous system trigger bFGF gene expression by neurons and/or activated astrocytes, depending on the type of lesion and time post-manipulation. The changes in bFGF messenger RNA are frequently accompanied by a subsequent increase of bFGF immunoreactivity in astrocytes in the lesioned pathway. The reactive astrocytes and injured neurons synthesize increased amount of bFGF, which may act as a paracrine/autocrine factor, protecting neurons from death and also stimulating neuronal plasticity and tissue repair.
引用
收藏
页码:231 / 241
页数:11
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