Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics

被引：11

作者：

Grigoriev, PA

Berg, A

Schlegel, R

Grafe, U

机构：

[1] Hans Knoll Inst Nat Prod Res, D-07745 Jena, Germany

[2] Russian Acad Sci, Inst Cell Biophys, Moscow, Russia

来源：

BIOELECTROCHEMISTRY AND BIOENERGETICS | 1997年 / 44卷 / 01期

关键词：

ampullosporin; bergofungin; artificial bilayer; ionophoric activities; channel formation; protonophoric differences;

D O I：

10.1016/S0302-4598(97)00063-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The membrane activity of new 15-membered peptaibol-type antibiotics, ampullosporin (I) from Sepedonium ampullosporum and bergofungin (II) from Emericellopsis donezkii, was tested by use of an artificial bilayer membrane, Bergofungin (II) conveys protons more efficiently than ampullosporin (I) suggesting that the-nature and the sequence of the constituting amino acids determine their special effect on ion penetration. (C) 1997 Elsevier Science S.A.

引用

页码：155 / 158

页数：4

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