Extranodal follicular dendritic cell tumour of the nasopharynx

被引：36

作者：

Beham-Schmid, C

Beham, A

Jakse, R

Auböck, L

Höfler, G

机构：

[1] Graz Univ, Sch Med, Inst Pathol, A-8036 Graz, Austria

[2] Krankenhaus Elisabethinen, Dept ENT, Graz, Austria

来源：

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY | 1998年 / 432卷 / 03期

关键词：

follicular dendritic cell tumour; nasopharynx; immunohistochemistry; electron microscopy; PCR;

D O I：

10.1007/s004280050168

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report the first case of an extranodal follicular dendritic cell (FDC) tumour localized in the nasopharynx of a 44-year-old male patient. The tumour cells were characterized immunohistochemically by strong expression of CD21, HLA-DR and vimentin and focal expression of CD68 and cytokeratin. Electron microscopic examination revealed desmosomal cell junctions between adjacent cell processes. Molecular genetic analysis using polymerase chain reaction (PCR) showed germline configuration of immunoglobulin and T-cell receptor genes. Epstein-Barr virus (EBV) genomes were detectable by PCR. After complete surgical tumour removal and radiotherapy the patient is disease-free 20 months after the initial diagnosis.

引用

页码：293 / 298

页数：6