ZDOCK predictions for the CAPRI Challenge

被引：64

作者：

Chen, R ^{[1
]}

Tong, WW ^{[1
]}

Mintseris, J ^{[1
]}

Li, L ^{[1
]}

Weng, ZP ^{[1
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Bioinformat Program, Boston, MA 02215 USA

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2003年 / 52卷 / 01期

关键词：

ZDOCK; CAPRI; blind test; protein docking; shape complementarity; desolvation; electrostatics;

D O I：

10.1002/prot.10388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CAPRI Challenge is a blind test of protein-protein-docking algorithms that predict the complex structure from the crystal structures of the interacting proteins. We participated in both rounds of this blind test and submitted predictions for all seven targets, relying mainly on our Fast Fourier Transform based algorithm ZDOCK that combines shape complementarity, desolvation, and electrostatics. Our group made good predictions for three targets and had at least some success with three others. Implications of the treatment of prior biological information as well as contributions of manual inspection to docking predictions are also discussed. (C) 2003 Wiley-Liss, Inc.

引用

页码：68 / 73

页数：6

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