Expeditious one-pot and solvent-free synthesis of dihydroquinazolin-4(1H)-ones in the presence of microwaves

被引：77

作者：

Surpur, Mandar P. ^{[1
]}

Singh, Pankajkumar R. ^{[1
]}

Patil, Sachin B. ^{[1
]}

Samant, Shriniwas D. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Chem, Organ Chem Res Lab, Bombay 400019, Maharashtra, India

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 12期

关键词：

dihydroquinazolin-4(1H)-ones; Amberlyst-15; microwaves; multicomponent reactions;

D O I：

10.1080/00397910701354699

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dihydroquinazolin-4(1H)-ones were synthesized for the first time by a novel three-component condensation of isatoic anhydride, a primary amine, and an aldehyde catalyzed by Amberlyst-15 in the presence of microwaves under neat conditions. The catalyst is reusable, thus making the process more environmentally friendly.

引用

页码：1965 / 1970

页数：6

共 25 条

[21] Some novel aspects of cationic ion-exchange resins as catalysts [J].

Sharma, MM .

REACTIVE & FUNCTIONAL POLYMERS, 1995, 26 (1-3) :3-23

[22] 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity [J].

Tsou, HR ;

Mamuya, N ;

Johnson, BD ;

Reich, MF ;

Gruber, BC ;

Ye, F ;

Nilakantan, R ;

Shen, R ;

Discafani, C ;

DeBlanc, R ;

Davis, R ;

Koehn, FE ;

Greenberger, LM ;

Wang, YF ;

Wissner, A .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (17) :2719-2734

[23] Solvent-free organic syntheses - using supported reagents and microwave irradiation [J].

Varma, RS .

GREEN CHEMISTRY, 1999, 1 (01) :43-55

[24] Solvent-free synthesis of heterocyclic compounds using microwaves [J].

Varma, RS .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1999, 36 (06) :1565-1571

[25] SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 2-SUBSTITUTED 3-ARYL-4(3H)-QUINAZOLINONES [J].

WOLFE, JF ;

RATHMAN, TL ;

SLEEVI, MC ;

CAMPBELL, JA ;

GREENWOOD, TD .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :161-166

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