F1F0 ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane

被引：74

作者：

van Bloois, E

Haan, GJ

de Gier, JW

Oudega, B

Luirink, J

机构：

[1] Free Univ Amsterdam, Inst Mol Cell Biol, Dept Mol Microbiol, NL-1081 HV Amsterdam, Netherlands

[2] Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden

来源：

FEBS LETTERS | 2004年 / 576卷 / 1-2期

关键词：

ATP synthase; signal recognition particle; YidC; protein targeting; membrane protein; E; coli;

D O I：

10.1016/j.febslet.2004.08.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane integration. We have examined the biogenesis of the F1F0 ATP synthase subunit c, a small double spanning IMP, using complementary in vivo and in vitro approaches. The data suggest that F(0)c is targeted by the SRP to the membrane, where it inserts at YidC in a Sec-independent mechanism. F(0)c appears to be the first natural substrate of this novel pathway. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：97 / 100

页数：4

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