F1F0 ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane

被引：74

作者：

van Bloois, E

Haan, GJ

de Gier, JW

Oudega, B

Luirink, J

机构：

[1] Free Univ Amsterdam, Inst Mol Cell Biol, Dept Mol Microbiol, NL-1081 HV Amsterdam, Netherlands

[2] Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden

来源：

FEBS LETTERS | 2004年 / 576卷 / 1-2期

关键词：

ATP synthase; signal recognition particle; YidC; protein targeting; membrane protein; E; coli;

D O I：

10.1016/j.febslet.2004.08.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane integration. We have examined the biogenesis of the F1F0 ATP synthase subunit c, a small double spanning IMP, using complementary in vivo and in vitro approaches. The data suggest that F(0)c is targeted by the SRP to the membrane, where it inserts at YidC in a Sec-independent mechanism. F(0)c appears to be the first natural substrate of this novel pathway. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：97 / 100

页数：4

相关论文

共 37 条

[31] Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome [J].

Ullers, RS ;

Houben, ENG ;

Raine, A ;

ten Hagen-Jongman, CM ;

Ehrenberg, M ;

Brunner, J ;

Oudega, B ;

Harms, N ;

Luirink, J .

JOURNAL OF CELL BIOLOGY, 2003, 161 (04) :679-684

[32] Targeting, insertion, and localization of Escherichia coli YidC [J].

Urbanus, ML ;

Fröderberg, L ;

Drew, D ;

Björk, P ;

de Gier, JWL ;

Brunner, J ;

Oudega, B ;

Luirink, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) :12718-12723

[33] Sec-dependent membrane protein insertion:: sequential interaction of nascent FtsQ with SecY and YidC [J].

Urbanus, ML ;

Scotti, PA ;

Fröderberg, L ;

Sääf, A ;

de Gier, JWL ;

Brunner, J ;

Samuelson, JC ;

Dalbey, RE ;

Oudega, B ;

Luirink, J .

EMBO REPORTS, 2001, 2 (06) :524-529

[34] F1F0 ATP synthase subunit c is a substrate of the novel YidC pathway for membrane protein biogenesis [J].

van der Laan, M ;

Bechtluft, P ;

Kol, S ;

Nouwen, N ;

Driessen, AJM .

JOURNAL OF CELL BIOLOGY, 2004, 165 (02) :213-222

[35] A conserved function of YidC in the biogenesis of respiratory chain complexes [J].

van der Laan, M ;

Urbanus, ML ;

ten Hagen-Jongman, CM ;

Nouwen, N ;

Oudega, B ;

Harms, N ;

Driessen, AJM ;

Luirink, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :5801-5806

[36] YidC is strictly required for membrane insertion of Subunits a and c of the F1F0ATP synthase and SecE of the SecYEG translocase [J].

Yi, L ;

Jiang, FL ;

Chen, MY ;

Cain, B ;

Bolhuis, A ;

Dalbey, RE .

BIOCHEMISTRY, 2003, 42 (35) :10537-10544

[37] Sec/SRP requirements and energetics of membrane insertion of subunits a, b, and c of the Escherichia coli F1F0 ATP synthase [J].

Yi, L ;

Celebi, N ;

Chen, MY ;

Dalbey, RE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (38) :39260-39267

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