Lessons from TGF-β transgenic mice

被引：24

作者：

Böttinger, EP

Kopp, JB

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Div Nephrol, Bronx, NY 10461 USA

[2] NIDDKD, Kidney Dis Sect, Metab Dis Branch, Bethesda, MD 20892 USA

来源：

MINERAL AND ELECTROLYTE METABOLISM | 1998年 / 24卷 / 2-3期

关键词：

TGF-beta; transgenic mice; disease; inflammation; fibrosis; development;

D O I：

10.1159/000057364

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes, Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.

引用

收藏

页码：154 / 160

页数：7

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