Metabolic Instruction of Immunity

被引：957

作者：

Buck, Michael D. ^{[1
,2
,3
]}

Sowell, Ryan T. ^{[4
]}

Kaech, Susan M. ^{[4
]}

Pearce, Erika L. ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol & Epigenet, Dept Immunometab, D-79108 Freiburg, Germany

[2] Washington Univ, Sch Med, Div Biol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Biomed Sci Immunol Program, St Louis, MO 63110 USA

[4] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

CELL | 2017年 / 169卷 / 04期

基金：

美国国家科学基金会;

关键词：

CD8(+) T-CELLS; GERMINAL CENTER HYPOXIA; FATTY-ACID-METABOLISM; REGULATORY T; GLYCOLYTIC METABOLISM; INTERLEUKIN-10; RECEPTOR; TUMOR MICROENVIRONMENT; AEROBIC GLYCOLYSIS; EFFECTOR FUNCTION; DENDRITIC CELL;

D O I：

10.1016/j.cell.2017.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.

引用

页码：570 / 586

页数：17

共 145 条

[1]

Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination [J].

Abbott, Robert K. ;

Thayer, Molly ;

Labuda, Jasmine ;

Silva, Murillo ;

Philbrook, Phaethon ;

Cain, Derek W. ;

Kojima, Hidefumi ;

Hatfield, Stephen ;

Sethumadhavan, Shalini ;

Ohta, Akio ;

Reinherz, Ellis L. ;

Kelsoe, Garnett ;

Sitkovsky, Michail .

JOURNAL OF IMMUNOLOGY, 2016, 197 (10) :4014-4020

[2]

Big opportunities for small molecules in immuno-oncology [J].

Adams, Jerry L. ;

Smothers, James ;

Srinivasan, Roopa ;

Hoos, Axel .

NATURE REVIEWS DRUG DISCOVERY, 2015, 14 (09) :603-622

[3]

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal [J].

Adams, William C. ;

Chen, Yen-Hua ;

Kratchmarov, Radomir ;

Yen, Bonnie ;

Nish, Simone A. ;

Lin, Wen-Hsuan W. ;

Rothman, Nyanza J. ;

Luchsinger, Larry L. ;

Klein, Ulf ;

Busslinger, Meinrad ;

Rathmell, Jeffrey C. ;

Snoeck, Hans-Willem ;

Reiner, Steven L. .

CELL REPORTS, 2016, 17 (12) :3142-3152

[4]

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism [J].

Allen, Bryan G. ;

Bhatia, Sudershan K. ;

Anderson, Carryn M. ;

Eichenberger-Gilmore, Julie M. ;

Sibenaller, Zita A. ;

Mapuskar, Kranti A. ;

Schoenfeld, Joshua D. ;

Buatti, John M. ;

Spitz, Douglas R. ;

Fath, Melissa A. .

REDOX BIOLOGY, 2014, 2 :963-970

[5]

mTOR regulates memory CD8 T-cell differentiation [J].

Araki, Koichi ;

Turner, Alexandra P. ;

Shaffer, Virginia Oliva ;

Gangappa, Shivaprakash ;

Keller, Susanne A. ;

Bachmann, Martin F. ;

Larsen, Christian P. ;

Ahmed, Rafi .

NATURE, 2009, 460 (7251) :108-U124

[6]

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[7]

Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function [J].

Balmer, Maria L. ;

Ma, Eric H. ;

Bantug, Glenn R. ;

Grahlert, Jasmin ;

Pfister, Simona ;

Glatter, Timo ;

Jauch, Annaise ;

Dimeloe, Sarah ;

Slack, Emma ;

Dehio, Philippe ;

Krzyzaniak, Magdalena A. ;

King, Carolyn G. ;

Burgener, Anne-Valerie ;

Fischer, Marco ;

Develioglu, Leyla ;

Belle, Reka ;

Recher, Mike ;

Bonilla, Weldy V. ;

Macpherson, Andrew J. ;

Hapfelmeier, Siegfried ;

Jones, Russell G. ;

Hess, Christoph .

IMMUNITY, 2016, 44 (06) :1312-1324

[8]

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion [J].

Bengsch, Bertram ;

Johnson, Andy L. ;

Kurachi, Makoto ;

Odorizzi, Pamela M. ;

Pauken, Kristen E. ;

Attanasio, John ;

Stelekati, Erietta ;

McLane, Laura M. ;

Paley, Michael A. ;

Delgoffe, Greg M. ;

Wherry, E. John .

IMMUNITY, 2016, 45 (02) :358-373

[9]

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells [J].

Berod, Luciana ;

Friedrich, Christin ;

Nandan, Amrita ;

Freitag, Jenny ;

Hagemann, Stefanie ;

Harmrolfs, Kirsten ;

Sandouk, Aline ;

Hesse, Christina ;

Castro, Carla N. ;

Baehres, Heike ;

Tschirner, Sarah K. ;

Gorinski, Nataliya ;

Gohmert, Melanie ;

Mayer, Christian T. ;

Huehn, Jochen ;

Ponimaskin, Evgeni ;

Abraham, Wolf-Rainer ;

Mueller, Rolf ;

Lochner, Matthias ;

Sparwasser, Tim .

NATURE MEDICINE, 2014, 20 (11) :1327-1333

[10]

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells [J].

Brand, Almut ;

Singer, Katrin ;

Koehl, Gudrun E. ;

Kolitzus, Marlene ;

Schoenhammer, Gabriele ;

Thiel, Annette ;

Matos, Carina ;

Bruss, Christina ;

Klobuch, Sebastian ;

Peter, Katrin ;

Kastenberger, Michael ;

Bogdan, Christian ;

Schleicher, Ulrike ;

Mackensen, Andreas ;

Ullrich, Evelyn ;

Fichtner-Feigl, Stefan ;

Kesselring, Rebecca ;

Mack, Matthias ;

Ritter, Uwe ;

Schmid, Maximilian ;

Blank, Christian ;

Dettmer, Katja ;

Oefner, Peter J. ;

Hoffmann, Petra ;

Walenta, Stefan ;

Geissler, Edward K. ;

Pouyssegur, Jacques ;

Villunger, Andreas ;

Steven, Andre ;

Seliger, Barbara ;

Schreml, Stephan ;

Haferkamp, Sebastian ;

Kohl, Elisabeth ;

Karrer, Sigrid ;

Berneburg, Mark ;

Herr, Wolfgang ;

Mueller-Klieser, Wolfgang ;

Renner, Kathrin ;

Kreutz, Marina .

Cell Metabolism, 2016, 24 (05) :657-671

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