Role of chemopreventive agents in cancer therapy

被引：422

作者：

Dorai, T

Aggarwal, BB

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Cytokine Res Sect, Houston, TX 77030 USA

[2] New York Med Coll, Our Lady Mercy Med Ctr, Ctr Comprehens Canc, Bronx, NY 10466 USA

来源：

CANCER LETTERS | 2004年 / 215卷 / 02期

关键词：

NF-kappa B; carcinogenesis; chemoprevention; chemotherapy; tumorigenesis; COX-2;

D O I：

10.1016/j.canlet.2004.07.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumorigenesis or carcinogenesis is a multi-step process that is induced primarily by carcinogens leading to the development of cancer. Extensive research in the last few years has revealed that regular consumption of certain fruits and vegetables can reduce the risk of acquiring specific cancers. Phytochemicals derived from such fruits and vegetables, referred to as chemopreventive agents include genistein, resveratrol, diallyl sulfide, S-allyl cysteine, allicin, lycopene, capsaicin, curcumin, 6-gingerol, ellagic acid, ursolic acid, silymarin, anethol, catechins and eugenol. Because these agents have been shown to suppress cancer cell proliferation, inhibit growth factor signaling pathways, induce apoptosis, inhibit NF-kappaB, AP-1 and JAKSTAT activation pathways, inhibit angiogenesis, suppress the expression of anti-apoptotic proteins, inhibit cyclooxygenase-2, they may have untapped therapeutic value. These chemopreventive agents also have very recently been found to reverse chemoresistance and radioresistance in patients undergoing cancer treatment. Thus, these chemopreventive agents have potential to be used as adjuncts to current cancer therapies. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：129 / 140

页数：12

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[11] Sanguinarine (pseudochelerythrine) is a potent inhibitor of NP-kappa B activation, I kappa B alpha phosphorylation, and degradation [J].