The role of Cdx genes in the gut and in axial development

被引：54

作者：

Beck, Felix ^{[1
]}

Stringer, Emma J. ^{[1
]}

机构：

[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷

关键词：

anal atresia; axial extension; Cdx; colon cancer; gut morphogenesis; intestinal heterolopia; HOMEOBOX GENE; INTESTINAL METAPLASIA; TRANSGENIC MICE; MUTANT MICE; EXPRESSION PATTERN; PROTEIN CDX-2; MOUSE STOMACH; DIFFERENTIATION; ELONGATION; EPITHELIUM;

D O I：

10.1042/BST0380353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Cdx (Caudal-type homeobox) group of ParaHox genes (Cdx1, Cdx2 and Cdx4 in the mouse) perform multiple functions in mammalian development. Cdx1 is concerned with axial positional information, and its deletion appears to have no important effect other than a disturbance of axial patterning In contrast, Cdx2 is required for trophoblast differentiation, axial patterning and extension, as well as for morphological specification (i.e. patterning) of gut endoderm. Cdx4-knockout animals do not present an abnormal phenotype, but, when combined with Cdx2 haploinsufficiency, present a dramatic picture involving abnormal cloacal specification. The latter is probably due in large part to defective paraxial mesodermal development in the caudal region, but may also involve defective endodermal growth. A significant degree of redundancy is apparent between the Cdx genes with respect to caudal extension and possibly also during gut development.

引用

页码：353 / 357

页数：5

共 32 条

[11] MURINE CDX-4 BEARS STRIKING SIMILARITIES TO THE DROSOPHILA-CAUDAL GENE IN ITS HOMEODOMAIN SEQUENCE AND EARLY EXPRESSION PATTERN [J].

GAMER, LW ;

WRIGHT, CVE .

MECHANISMS OF DEVELOPMENT, 1993, 43 (01) :71-81

[12] Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2 [J].

Gao, Nan ;

White, Peter ;

Kaestner, Klaus H. .

DEVELOPMENTAL CELL, 2009, 16 (04) :588-599

[13] Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation [J].

Gross, I ;

Lhermitte, B ;

Domon-Dell, C ;

Duluc, I ;

Martin, E ;

Gaiddon, C ;

Kedinger, M ;

Freund, JN .

ONCOGENE, 2005, 24 (54) :7955-7963

[14]

IAM PP, 2007, DEVELOPMENT, V134, P251

[15] Roles of caudal-related homeobox gene Cdx1 in oesophageal epithelial cells in Barrett's epithelium development [J].

Kazumori, H. ;

Ishihara, S. ;

Kinoshita, Y. .

GUT, 2009, 58 (05) :620-628

[16] The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling [J].

Kim, BM ;

Buchner, G ;

Miletich, I ;

Sharpe, PT ;

Shivdasani, RA .

DEVELOPMENTAL CELL, 2005, 8 (04) :611-622

[17] Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen [J].

Kim, Byeong-Moo ;

Miletich, Isabelle ;

Mao, Junhao ;

McMahon, Andrew P. ;

Sharpe, Paul A. ;

Shivdasani, Ramesh A. .

DEVELOPMENT, 2007, 134 (20) :3603-3613

[18] cis-acting elements and transcription factors involved in the intestinal specific expression of the rat calbindin-D9k gene - Binding of the intestine-specific transcription factor Cdx-2 to the TATA box [J].

Lambert, M ;

Colnot, S ;

Suh, E ;

LHorset, F ;

Blin, C ;

Calliot, ME ;

Raymondjean, M ;

Thomasset, M ;

Traber, PG ;

Perret, C .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 236 (03) :778-788

[19] Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice [J].

Mutoh, H ;

Sakurai, S ;

Satoh, K ;

Osawa, H ;

Hakamata, Y ;

Takeuchi, T ;

Sugano, K .

GUT, 2004, 53 (10) :1416-1423

[20] Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice [J].

Mutoh, H ;

Hakamata, Y ;

Sato, K ;

Eda, A ;

Yanaka, I ;

Honda, S ;

Osawa, H ;

Kaneko, Y ;

Sugano, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 294 (02) :470-479

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