Genotoxicity evaluation of norethisterone acetate

被引：15

作者：

Dhillon, VS ^{[1
]}

Dhillon, IK ^{[1
]}

机构：

[1] GURU NANAK DEV UNIV, DEPT HUMAN GENET, AMRITSAR 143005, PUNJAB, INDIA

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1996年 / 367卷 / 01期

关键词：

Ames test; human lymphocyte; sister chromatid exchange (SCE); micronucleus; chromosomal aberration; S9; mix; norethisterone acetate;

D O I：

10.1016/S0165-1218(96)90016-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genotoxic evaluation of a commonly used progestogen, norethisterone acetate, was undertaken using a combination of short-term in vitro and in vivo assays. The clastogenic potentiality of norethisterone acetate was evident from the chromosome aberrations and sister chromatid exchanges induced both with and without S9 mix in cultured human lymphocytes and also from the increased frequency of micronuclei formation and sister chromatid exchanges in mice. However, in the Ames Salmonella assay, both with and without S9 mix and in host-mediated assay, norethisterone acetate was unable to cause any significant increase/decrease in the His(+) revertants/plate.

引用

页码：1 / 10

页数：10

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