Genetic polymorphism in CYP17 and breast cancer risk in Japanese women

被引：46

作者：

Miyoshi, Y ^{[1
]}

Iwao, K ^{[1
]}

Ikeda, N ^{[1
]}

Egawa, C ^{[1
]}

Noguchi, S ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Dept Surg Oncol, Suita, Osaka 5650871, Japan

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 18期

关键词：

CYP17; polymorphism; breast cancer; oestrogen;

D O I：

10.1016/S0959-8049(00)00334-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case-control study was conducted to investigate the association of two genetic polymorphisms (1931T/C and 1951G/A) in the promoter region of the CYP17 gene with breast cancer risk in Japanese women. No significant association was observed between CYP17 polymorphism(1951G/A) and breast cancer risk (odds ratio (OR) = 1.71, 95% confidence interval (CI): 0.28-1.84). In contrast, a significant increase in breast cancer risk (OR = 1.82, 95% CI: 1.07-3.12) was observed. in Cyp17(1931C/C) homozygotes compared with Cyp17(1931T/C) heterozygotes and Cyp17(1931T/T) homozygotes when women aged greater than or equal to 55 years were considered, but such a significant increase was not observed when women aged less than or equal to 54 years were considered (OR = 0.96, 95% CI: 0.56-1.63). These results suggest that CYP17 polymorphism(1931T/C) would be useful in the selection of Japanese women at a high risk for developing breast cancer at the age of greater than or equal to 55 years. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2375 / 2379

页数：5