Olfactory ensheathing cell transplantation as a strategy for spinal cord repair - what can it achieve?

被引:98
作者
Barnett, Susan C.
Riddell, John S.
机构
[1] Univ Glasgow, Canc Res UK Beatson Labs, Div Clin Neurosci, Glasgow G12 8QQ, Lanark, Scotland
[2] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
来源
NATURE CLINICAL PRACTICE NEUROLOGY | 2007年 / 3卷 / 03期
基金
英国惠康基金;
关键词
cell transplantation; neuroprotection; olfactory ensheathing cells; spinal cord injury;
D O I
10.1038/ncpneuro0447
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Restoring function to the injured spinal cord represents one of the most formidable challenges in regenerative medicine. Glial cell transplantation is widely considered to be one of the most promising therapeutic strategies, and several differentiated glial cell types-in particular, Schwann cells and olfactory ensheathing cells (OECs)-have been proposed as transplant candidates. In this Review, we analyze evidence from animal studies for improved functional recovery following transplantation of OECs into spinal cord injuries, and examine the mechanisms by which repair might be achieved. Data obtained using various injury models support the view that OEC transplants can promote functional recovery, but accumulating anatomical evidence indicates that although axons regenerate within a transplant, they do not cross the lesion or reconnect with neurons on the opposite side to any significant extent. Consequently, it is possible that neuroprotection and promotion of sprouting from intact fibers are the main mechanisms that contribute to functional recovery. We conclude that for the foreseeable future the clinical benefits of OEC transplants alone are likely to be modest. The future potential of cell transplantation strategies will probably depend on the success with which the transplants can be combined with other, synergistic, therapies to achieve significant regeneration of axons and re-establish functionally useful connections across a spinal cord injury.
引用
收藏
页码:152 / 161
页数:10
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