Targeting the tumour vasculature: insights from physiological angiogenesis

被引：698

作者：

Chung, Alicia S. ^{[1
]}

Lee, John ^{[1
]}

Ferrara, Napoleone ^{[1
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 07期

关键词：

ENDOTHELIAL GROWTH-FACTOR; BLOOD-VESSEL FORMATION; GLAND-DERIVED VEGF; FACTOR RECEPTOR-1; EXTRACELLULAR-MATRIX; STROMAL FIBROBLASTS; MAST-CELLS; PDGF-C; TIE2-EXPRESSING MONOCYTES; MOLECULAR REGULATION;

D O I：

10.1038/nrc2868

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The cardiovascular system ensures the delivery of nutrients, oxygen, and blood and immune cells to all organs and tissues: it is also responsible for the removal of waste metabolites. The vascular system develops and matures through two tightly regulated processes: vasculogenesis and angiogenesis. Angiogenesis is active only under specific physiological conditions in healthy adults but the vasculature can be aberrantly activated to generate new blood vessels during pathological conditions such as cancer and chronic inflammation. In this Opinion article we discuss the parallels and differences in the angiogenic process under either a physiological or a pathological state, especially tumorigenesis.

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收藏

页码：505 / 514

页数：10

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