Rh Catalyzed Olefination and Vinylation of Unactivated Acetanilides

被引：369

作者：

Patureau, Frederic W. ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 29期

关键词：

H BOND ACTIVATION; C-H; AROMATIC SUBSTITUTION; PD(II)-CATALYZED OLEFINATION; DIRECT ARYLATION; BENZOIC-ACIDS; FUNCTIONALIZATION; INDOLES; ALKYNES; ALKENYLATION;

D O I：

10.1021/ja103834b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the catalyzed oxidative olefination of acetanilides (oxidative-Heck coupling), Rh offers great advantages over more common Pd catalysts. Lower catalyst loadings, large functional group tolerance (in particular to halides), and higher reactivity of electron-neutral olefins (styrenes) are some of the attractive features. Most interestingly, even ethylene reacts to yield the corresponding acetanilido-styrene. Moreover, the Cu(II) oxidant can also be utilized in catalytic amounts with air serving as the terminal oxidant.

引用

页码：9982 / 9983

页数：2

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