Dextromethorphan Exhibits Anti-inflammatory and Immunomodulatory Effects in a Murine Model of Collagen-Induced Arthritis and in Human Rheumatoid Arthritis

被引：16

作者：

Chen, Der-Yuan ^{[1
,2
,3
,4
,5
]}

Lin, Chi-Chien ^{[2
,3
,6
,7
]}

Chen, Yi-Ming ^{[1
,2
,3
,4
]}

Chao, Ya-Hsuan ^{[2
,3
]}

Yang, Deng-Ho ^{[8
,9
,10
]}

机构：

[1] Taichung Vet Gen Hosp, Div Allergy Immunol & Rheumatol, Taichung, Taiwan

[2] Natl Chung Hsing Univ, Inst Biomed Sci, Taichung, Taiwan

[3] Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, Taichung, Taiwan

[4] Natl Yang Ming Univ, Fac Med, Taipei, Taiwan

[5] Chung Shan Med Univ, Inst Microbiol & Immunol, Taichung, Taiwan

[6] Asia Univ, Dept Biotechnol, Taichung, Taiwan

[7] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[8] Taichung Armed Forces Gen Hosp, Dept Internal Med, Div Rheumatol Immunol Allergy, Taichung, Taiwan

[9] Cent Taiwan Univ Sci & Technol, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan

[10] Natl Def Med Ctr, Triserv Gen Hosp, Dept Internal Med, Div Rheumatol Immunol Allergy, Taipei, Taiwan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

OXIDATIVE STRESS; DOUBLE-BLIND; II COLLAGEN; GM-CSF; CYTOKINE; DISEASE; INFLAMMATION; AGENTS;

D O I：

10.1038/s41598-017-11378-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Dextromethorphan (d-3-methoxy-17-methylmorphinan, DXM) is a commonly used antitussive with a favorable safety profile. Previous studies have demonstrated that DXM has anti-inflammatory and immunomodulatory properties; however, the effect of DXM in rheumatoid arthritis (RA) remains unknown. Herein, we found that DXM treatment attenuated arthritis severity and proinflammatory cytokine expression levels, including TNF-alpha, IL-6, and IL-17A, in paw tissues of CIA mice. DXM treatment also reduced serum TNF-alpha, IL-6, and IL-17A levels of CIA mice and patients with RA. DXM further decreased the production of anti-CII IgG, IFN-gamma, and IL-17A in collagen-reactive CD4(+) T cells extracted from the lymph nodes of CIA mice. In vitro incubation of bone marrow-derived dendritic cells with DXM limited CD4(+) T-cell proliferation and inflammatory cytokine secretion. In conclusion, our results showed that DXM attenuated arthritis symptoms in CIA mice and significantly reduced proinflammatory cytokines in patients with RA, suggesting that it can be used as an anti-arthritic agent.

引用

页数：14

共 42 条

[1]

GM-CSF: An immune modulatory cytokine that can suppress autoimmunity [J].