Genetic analysis of homologous DNA recombination in vertebrate somatic cells

被引：32

作者：

Morrison, C

Takeda, S ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Bayer Chair, Dept Mol Immunol & Allergol,Sakyo Ku, Kyoto 6068501, Japan

[2] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH3 9JR, Midlothian, Scotland

[3] Kyoto Univ, Sch Med, Dept Radiat Biol, Sakyo Ku, Kyoto 6068501, Japan

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2000年 / 32卷 / 08期

关键词：

DNA repair; DT40; homologous recombination; gene targeting; knockouts;

D O I：

10.1016/S1357-2725(00)00033-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The maintenance of genomic stability and the ability to repair induced DNA damage in vertebrate cells require homologues of the yeast RAD52 epistasis group genes. The homologous recombination carried out by the products of these genes is essential and appears to be closely linked to DNA replication. Defects in recombination and associated activities are implicated in human cancer. This review summarises recent biochemical and genetic findings on the roles played by the vertebrate RAD52 group gene products in recombination. We describe the phenotypic analysis of genetically engineered mammalian and chicken mutants of homologous recombination genes. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：817 / 831

页数：15

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