Local IgE production

被引：22

作者：

Durham, SR ^{[1
]}

Smurthwaite, L ^{[1
]}

Gould, HJ ^{[1
]}

机构：

[1] Natl Heart & Lung Inst, Imperial Coll Sch Med, London SW3 6LY, England

来源：

AMERICAN JOURNAL OF RHINOLOGY | 2000年 / 14卷 / 05期

关键词：

D O I：

10.2500/105065800781329492

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Recent data from a number of groups have confirmed that IgE antibody may be produced, at least in part, locally within the nasal mucosa. Our data support the theory that B cell switching may also occur locally, although this remains to be confirmed. Local IgE may account for local disease expression in atopic subjects, although it is not clear which step is rate-limiting in this process. Our results highlight the importance of developing local strategies targeted against IgE for treatment of allergic diseases.

引用

页码：305 / 307

页数：3