Characterization of two receptors for TRAIL

被引：246

作者：

Schneider, P

Bodmer, JL

Thome, M

Hofmann, K

Holler, N

Tschopp, J

机构：

[1] UNIV LAUSANNE,INST BIOCHEM,CH-1066 EPALINGES,SWITZERLAND

[2] SWISS INST EXPT CANC RES,BIL RES CTR,CH-1066 EPALINGES,SWITZERLAND

来源：

FEBS LETTERS | 1997年 / 416卷 / 03期

关键词：

apoptosis; death receptor; TRAIL; tumor necrosis factor;

D O I：

10.1016/S0014-5793(97)01231-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified, Both are members of the tumor necrosis factor receptor family, TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-RI (DR-4), and is capable of inducing apoptosis, In contrast, TRAIL-R3 does not promote cell death, TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor, The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline-and glutamine-rich repeats (TAPE repeats), TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle, All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals. (C) 1997 Federation of European Biochemical Societies.

引用

页码：329 / 334

页数：6

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