Routine measurement of fluoxetine and norfluoxetine by high-performance liquid chromatography with ultraviolet detection in patients under concomitant treatment with tricyclic antidepressants

被引：27

作者：

Meineke, I ^{[1
]}

Schreeb, K ^{[1
]}

Kress, I ^{[1
]}

Gundert-Remy, U ^{[1
]}

机构：

[1] Univ Gottingen, Dept Clin Pharmacol, D-37075 Gottingen, Germany

来源：

THERAPEUTIC DRUG MONITORING | 1998年 / 20卷 / 01期

关键词：

fluoxetine; TCA; HPLC; concentration-effect relationship;

D O I：

10.1097/00007691-199802000-00003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A robust and rapid high-performance liquid chromatography (HPLC) method is described for therapeutic drug monitoring of fluoxetine and norfluoxetine in the presence of six frequently-used tricyclic antidepressants and their respective metabolites. Liquid-liquid extraction into n-hexane/acetonitrile is used with reextraction into hydrochloric acid for clean-up. The chromatographic separation is carried out on a CN column. The minimum detectable amount is 3 ng injected on column. In addition to qualitative and quantitative validation data for the assay method, results from patient samples are presented. It is concluded that for patients treated with fluoxetine, therapeutic drug monitoring is valuable for optimizing the therapy.

引用

页码：14 / 19

页数：6

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