Mesenchymal stem cell-based cartilage tissue engineering: cells, scaffold and biology

被引：76

作者：

Song, L ^{[1
]}

Baksh, D ^{[1
]}

Tuan, RS ^{[1
]}

机构：

[1] NIAMSD, Cartilage Biol & Orthoped Branch, NIH, US Dept HHS, Bethesda, MD 20892 USA

来源：

CYTOTHERAPY | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1080/14653240410005276-1

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cartilage repair and regeneration by stem cell-based tissue engineering could be of enormous therapeutic and economic potential benefit for an aging population. However, to use stem cells effectively, their natural environment must be understood in order to expand them in vitro without compromising their multilineage potential and their specific differentiation program. Collaboration between diverse academic disciplines and between research and regulatory government agencies and industry is crucial before cell-based cartilage tissue engineering can achieve its full therapeutic potential.

引用

页码：596 / 601

页数：6

共 10 条

[1]

BOLAND GM, 2004, IN PRESS J CELL BICH

[2] Electrospun nanofibrous structure: A novel scaffold for tissue engineering [J].

Li, WJ ;

Laurencin, CT ;

Caterson, EJ ;

Tuan, RS ;

Ko, FK .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 60 (04) :613-621

[3] Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(ε-caprolactone) scaffolds [J].

Li, WJ ;

Danielson, KG ;

Alexander, PG ;

Tuan, RS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 67A (04) :1105-1114

[4] In vitro engineered cartilage constructs produced by press-coating biodegradable polymer with human mesenchymal stem cells [J].

Nöth, U ;

Tuli, R ;

Osyczka, AM ;

Danielson, KG ;

Tuan, RS .

TISSUE ENGINEERING, 2002, 8 (01) :131-144

[5] Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells [J].

Nöth, U ;

Osyczka, AM ;

Tuli, R ;

Hickok, NJ ;

Danielson, KG ;

Tuan, RS .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2002, 20 (05) :1060-1069

[6] Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow [J].

Song, L ;

Tuan, RS .

FASEB JOURNAL, 2004, 18 (06) :980-+

[7] Adult mesenchymal stem cells and cell-based tissue engineering [J].

Tuan, RS ;

Boland, G ;

Tuli, R .

ARTHRITIS RESEARCH & THERAPY, 2003, 5 (01) :32-45

[8] Transforming growth factor-β-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogenactivated protein kinase and Wnt signaling cross-talk [J].

Tuli, R ;

Tuli, S ;

Nandi, S ;

Huang, XX ;

Manner, PA ;

Hozack, WJ ;

Danielson, KG ;

Hall, DJ ;

Tuan, RS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :41227-41236

[9] Characterization of multipotential mesenchymal progenitor cells derived from human trabecular bone [J].

Tuli, R ;

Tuli, S ;

Nandi, S ;

Wang, ML ;

Alexander, PG ;

Haleem-Smith, H ;

Hozack, WJ ;

Manner, PA ;

Danielson, KG ;

Tuan, RS .

STEM CELLS, 2003, 21 (06) :681-693

[10]

TULI R, 2004, TISSUE ENG, V5, P1159

← 1 →