Mycobacterium tuberculosis-driven processes in gene-disrupted mice

被引：11

作者：

Cooper, AM ^{[1
]}

Saunders, BM ^{[1
]}

DSouza, CD ^{[1
]}

Frank, AA ^{[1
]}

Orme, IM ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT PATHOL,FT COLLINS,CO 80523

来源：

BULLETIN DE L INSTITUT PASTEUR | 1997年 / 95卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0020-2452(97)83916-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice which have disrupted genes for important components of the immune system have been used to study the role of these components in the immune response to infection with Mycobacterium tuberculosis. This has resulted in the identification of interleukin-12 (IL12), interferon-gamma (IFN gamma), tumour necrosis factor-alpha (TNF alpha) and inducible nitric oxide synthase (iNOS) as being essential to the protective response. Less crucial but perhaps more intriguing roles for other molecules such as intercellular adhesion molecule (ICAM) and IL6 have also been suggested by this kind of analysis.

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收藏

页码：85 / 96

页数：12

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