Costimulation in antiviral immunity:: differential requirements for CD4+ and CD8+ T cell responses

被引：121

作者：

Whitmire, JK

Ahmed, R

机构：

[1] La Jolla Inst Allergy & Immunol, Dept Mol Immunol, San Diego, CA 92121 USA

[2] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00119-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4(+) and CD8(+) T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.

引用

收藏

页码：448 / 455

页数：8

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