Costimulation in antiviral immunity:: differential requirements for CD4+ and CD8+ T cell responses

被引：121

作者：

Whitmire, JK

Ahmed, R

机构：

[1] La Jolla Inst Allergy & Immunol, Dept Mol Immunol, San Diego, CA 92121 USA

[2] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00119-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4(+) and CD8(+) T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.

引用

收藏

页码：448 / 455

页数：8

相关论文

共 68 条

[31] CD4(+) T-CELLS ARE REQUIRED TO SUSTAIN CD8(+) CYTOTOXIC T-CELL RESPONSES DURING CHRONIC VIRAL-INFECTION [J].

MATLOUBIAN, M ;

CONCEPCION, RJ ;

AHMED, R .

JOURNAL OF VIROLOGY, 1994, 68 (12) :8056-8063

[32]

Maxwell JR, 1999, J IMMUNOL, V162, P2024

[33] B7 costimulation is critical for antibody class switching and CD8+ cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus [J].

McAdam, AJ ;

Farkash, EA ;

Gewurz, BE ;

Sharpe, AH .

JOURNAL OF VIROLOGY, 2000, 74 (01) :203-208

[34] Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation [J].

Moran, M ;

Miceli, MC .

IMMUNITY, 1998, 9 (06) :787-796

[35] Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection [J].

Murali-Krishna, K ;

Altman, JD ;

Suresh, M ;

Sourdive, DJD ;

Zajac, AJ ;

Miller, JD ;

Slansky, J ;

Ahmed, R .

IMMUNITY, 1998, 8 (02) :177-187

[36] Protection of adult but not newborn mice against lethal intracerebral challenge with Japanese encephalitis virus by adoptively transferred virus-specific cytotoxic T lymphocytes: Requirement for L3T4(+) T cells [J].

MuraliKrishna, K ;

Ravi, V ;

Manjunath, R .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :705-714

[37] Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand [J].

Murata, K ;

Ishii, N ;

Takano, H ;

Miura, S ;

Ndhlovu, LC ;

Nose, M ;

Noda, T ;

Sugamura, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (02) :365-374

[38]

MUZUOCHI T, 1989, J IMMUNOL, V142, P270

[39] CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4(+) T cell functions [J].

Oxenius, A ;

Campbell, KA ;

Maliszewski, CR ;

Kishimoto, T ;

Kikutani, H ;

Hengartner, H ;

Zinkernagel, RM ;

Bachmann, MF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2209-2218

[40] MAJOR EXPANSION OF CD8+ T-CELLS WITH A PREDOMINANT V-BETA USAGE DURING THE PRIMARY IMMUNE-RESPONSE TO HIV [J].

PANTALEO, G ;

DEMAREST, JF ;

SOUDEYNS, H ;

GRAZIOSI, C ;

DENIS, F ;

ADELSBERGER, JW ;

BORROW, P ;

SAAG, MS ;

SHAW, GM ;

SEKALY, RP ;

FAUCI, AS .

NATURE, 1994, 370 (6489) :463-467

← 1 2 3 4 5 6 7 →