Neurotrophins in myelination: a new role for a puzzling receptor

被引：28

作者：

Notterpek, L ^{[1
]}

机构：

[1] Univ Florida, Coll Med, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 05期

关键词：

D O I：

10.1016/S0166-2236(03)00099-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Binding of neurotrophins to p75(NTR) was recently identified as a positive signal for myelination by Schwann cells. This new finding adds yet another distinct biological role to the growing list of functions of p75(NTR) in the nervous system and identifies a novel target for promoting remyelination in peripheral neuropathies or post-nerve-injury.

引用

页码：232 / 234

页数：3

共 17 条

[1]

Bentley CA, 2000, J NEUROSCI, V20, P7706

[2] Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 [J].

Carter, BD ;

Kaltschmidt, C ;

Kaltschmidt, B ;

Offenhauser, N ;

BohmMatthaei, R ;

Baeuerle, PA ;

Barde, YA .

SCIENCE, 1996, 272 (5261) :542-545

[3] Reduced size of retinal ganglion cell axone and hypomyelination in mice lacking brain-derived neurotrophic factor [J].

Cellerino, A ;

Carroll, P ;

Thoenen, H ;

Barde, YA .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1997, 9 (5-6) :397-408

[4] Neurotrophins are key mediators of the myelination program in the peripheral nervous system [J].

Chan, JR ;

Cosgaya, JM ;

Wu, YJ ;

Shooter, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14661-14668

[5] Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor [J].

Chittka, A ;

Chao, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10705-10710

[6] The neurotrophin receptor p75NTR as a positive modulator of myelination [J].

Cosgaya, JM ;

Chan, JR ;

Shooter, EM .

SCIENCE, 2002, 298 (5596) :1245-1248

[7] Actin plays a role in both changes in cell shape and gene-expression associated with Schwann cell myelination [J].

FernandezValle, C ;

Gorman, D ;

Gomez, AM ;

Bunge, MB .

JOURNAL OF NEUROSCIENCE, 1997, 17 (01) :241-250

[8] Myelin synthesis in the peripheral nervous system [J].

Garbay, B ;

Heape, AM ;

Sargueil, F ;

Cassagne, C .

PROGRESS IN NEUROBIOLOGY, 2000, 61 (03) :267-304

[9] Neurotrophins: Roles in neuronal development and function [J].

Huang, EJ ;

Reichardt, LF .

ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :677-736

[10] TARGETED MUTATION OF THE GENE ENCODING THE LOW AFFINITY NGF RECEPTOR P75 LEADS TO DEFICITS IN THE PERIPHERAL SENSORY NERVOUS-SYSTEM [J].

LEE, KF ;

LI, E ;

HUBER, LJ ;

LANDIS, SC ;

SHARPE, AH ;

CHAO, MV ;

JAENISCH, R .

CELL, 1992, 69 (05) :737-749

← 1 2 →