Does complexity belie a simple decision - on the Efroni and Cohen critique of the minimal model for a self-nonself discrimination

被引：4

作者：

Cohn, M ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Conceptual Immunol rp, La Jolla, CA 92037 USA

来源：

CELLULAR IMMUNOLOGY | 2003年 / 221卷 / 02期

关键词：

self-nonself discrimination; sorting repertoire; T-helper; models of tolerance; associative recognition of antigen;

D O I：

10.1016/S0008-8749(03)00075-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The immune system somatically generates a large and random paratopic repertoire that must be sorted into those specificities (anti-self) which, if expressed, would debilitate the host and those specificities (anti-nonself) which, if not expressed, would leave the host unprotected from infection. The critique of Efroni and Cohen that minimal models are misleading and without heuristic value is evaluated by illustrative examples. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：138 / 142

页数：5

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