Cerebral cortical phospholipase A2 activity of senescence-accelerated mouse is increased in an age-dependent manner

被引：12

作者：

Kim, SS

Kim, DK

Suh, YH

机构：

[1] Seoul Natl Univ, Coll Med, Dept Pharmacol, Seoul 110799, South Korea

[2] Seoul Natl Univ, Dept Mol Biol, Neurosci Res Inst, Seoul 110799, South Korea

[3] Chung Ang Univ, Coll Pharm, Dept Environm & Hlth Chem, Seoul 156756, South Korea

来源：

NEUROSCIENCE RESEARCH | 1997年 / 29卷 / 03期

关键词：

aging; phospholipase A(2); senescence-accelerated mouse; cerebral cortex;

D O I：

10.1016/S0168-0102(97)00098-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The PLA(2) activities of both the cytosolic and the membrane fractions from the cerebral cortex of 17-month old senescence-accelerated mouse-prone/10 (SAM-P/10) were significantly increased by 1.3 times compared with those of 2-month old mice. The PLA(2) activities were independent of Ca2+ ion and not affected either by dithiothreitol (DTT) or by trifluoromethyl ketone analogs of arachidonic acid (AACOCF(3)). The PLA(2) activities were eluted in a single peak of molecular mass of 170 kDa, using a gel filtration column. These findings suggest that the enhanced PLA(2) activity may be related to neuronal degeneration and accelerated senescence of SAM-P/10, and cerebral cortical PLA(2) activity categorized as a Ca2+-independent PLA(2). (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：269 / 272

页数：4

共 19 条

[1] LEVELS OF PHOSPHOLIPID CATABOLIC INTERMEDIATES, GLYCEROPHOSPHOCHOLINE AND GLYCEROPHOSPHOETHANOLAMINE, ARE ELEVATED IN BRAINS OF ALZHEIMERS-DISEASE BUT NOT OF DOWNS-SYNDROME PATIENTS [J].