Genome-wide association study of Arabidopsis thaliana leaf microbial community

被引：265

作者：

Horton, Matthew W. ^{[1
,2
]}

Bodenhausen, Natacha ^{[1
]}

Beilsmith, Kathleen ^{[1
]}

Meng, Dazhe ^{[2
]}

Muegge, Brian D. ^{[3
]}

Subramanian, Sathish ^{[3
]}

Vetter, M. Madlen ^{[1
]}

Vilhjalmsson, Bjarni J. ^{[2
]}

Nordborg, Magnus ^{[2
]}

Gordon, Jeffrey I. ^{[3
]}

Bergelson, Joy ^{[1
]}

机构：

[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[2] Austrian Acad Sci, Gregor Mendel Inst, A-1030 Vienna, Austria

[3] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

关键词：

NATURAL VARIATION; MODEL APPROACH; DIVERSITY; RESISTANCE; HERITABILITY; ACCESSIONS; PUBESCENCE; TRICHOME; PATTERNS; BACTERIA;

D O I：

10.1038/ncomms6320

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.

引用

页数：7

共 57 条

[21] Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene GRIN2A as a Parkinson's Disease Modifier Gene via Interaction with Coffee [J].

Hamza, Taye H. ;

Chen, Honglei ;

Hill-Burns, Erin M. ;

Rhodes, Shannon L. ;

Montimurro, Jennifer ;

Kay, Denise M. ;

Tenesa, Albert ;

Kusel, Victoria I. ;

Sheehan, Patricia ;

Eaaswarkhanth, Muthukrishnan ;

Yearout, Dora ;

Samii, Ali ;

Roberts, John W. ;

Agarwal, Pinky ;

Bordelon, Yvette ;

Park, Yikyung ;

Wang, Liyong ;

Gao, Jianjun ;

Vance, Jeffery M. ;

Kendler, Kenneth S. ;

Bacanu, Silviu-Alin ;

Scott, William K. ;

Ritz, Beate ;

Nutt, John ;

Factor, Stewart A. ;

Zabetian, Cyrus P. ;

Payami, Haydeh .

PLOS GENETICS, 2011, 7 (08)

[22] Microtubules and biotic interactions [J].

Hardham, Adrienne R. .

PLANT JOURNAL, 2013, 75 (02) :278-289

[23]

Harris MA, 2008, NUCLEIC ACIDS RES, V36, pD440, DOI 10.1093/nar/gkm883

[24] DIVERSITY AND EVENNESS: A UNIFYING NOTATION AND ITS CONSEQUENCES [J].

HILL, MO .

ECOLOGY, 1973, 54 (02) :427-432

[25] MARTA: a suite of Java']Java-based tools for assigning taxonomic status to DNA sequences [J].

Horton, Matthew ;

Bodenhausen, Natacha ;

Bergelson, Joy .

BIOINFORMATICS, 2010, 26 (04) :568-569

[26] Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel [J].

Horton, Matthew W. ;

Hancock, Angela M. ;

Huang, Yu S. ;

Toomajian, Christopher ;

Atwell, Susanna ;

Auton, Adam ;

Muliyati, N. Wayan ;

Platt, Alexander ;

Sperone, F. Gianluca ;

Vilhjalmsson, Bjarni J. ;

Nordborg, Magnus ;

Borevitz, Justin O. ;

Bergelson, Joy .

NATURE GENETICS, 2012, 44 (02) :212-216

[27] Both Leaf Properties and Microbe-Microbe Interactions Influence Within-Species Variation in Bacterial Population Diversity and Structure in the Lettuce (Lactuca Species) Phyllosphere [J].

Hunter, Paul J. ;

Hand, Paul ;

Pink, David ;

Whipps, John M. ;

Bending, Gary D. .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2010, 76 (24) :8117-8125

[28] Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels [J].

Igl, Wilmar ;

Johansson, Asa ;

Wilson, James F. ;

Wild, Sarah H. ;

Polasek, Ozren ;

Hayward, Caroline ;

Vitart, Veronique ;

Hastie, Nicholas ;

Rudan, Pavao ;

Gnewuch, Carsten ;

Schmitz, Gerd ;

Meitinger, Thomas ;

Pramstaller, Peter P. ;

Hicks, Andrew A. ;

Oostra, Ben A. ;

van Duijn, Cornelia M. ;

Rudan, Igor ;

Wright, Alan ;

Campbell, Harry ;

Gyllensten, Ulf .

PLOS GENETICS, 2010, 6 (01)

[29] An Arabidopsis callose synthase, GSL5, is required for wound and papillary callose formation [J].

Jacobs, AK ;

Lipka, V ;

Burton, RA ;

Panstruga, R ;

Strizhov, N ;

Schulze-Lefert, P ;

Fincher, GB .

PLANT CELL, 2003, 15 (11) :2503-2513

[30] Variance component model to account for sample structure in genome-wide association studies [J].

Kang, Hyun Min ;

Sul, Jae Hoon ;

Service, Susan K. ;

Zaitlen, Noah A. ;

Kong, Sit-yee ;

Freimer, Nelson B. ;

Sabatti, Chiara ;

Eskin, Eleazar .

NATURE GENETICS, 2010, 42 (04) :348-U110

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