NF-κB signaling modulation by EBV and KSHV

被引：109

作者：

de Oliveira, Deilson Elgui ^{[1
]}

Ballon, Gianna ^{[2
]}

Cesarman, Ethel ^{[2
]}

机构：

[1] Sao Paulo State Univ UNESP, Botucatu Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil

[2] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA

来源：

TRENDS IN MICROBIOLOGY | 2010年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

EPSTEIN-BARR-VIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; PROTEIN-COUPLED RECEPTOR; PRIMARY-EFFUSION LYMPHOMA; GROWTH-FACTOR-RECEPTOR; ENDOTHELIAL-CELLS; LATENT MEMBRANE-PROTEIN-1; INDUCED APOPTOSIS; ACTIVATION; HUMAN-HERPESVIRUS-8;

D O I：

10.1016/j.tim.2010.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear factor (NF)-kappa B signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gamma-herpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappa B signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappa B modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.

引用

页码：248 / 257

页数：10

共 84 条

[1] Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis [J].

Akula, SM ;

Naranatt, PP ;

Walia, NS ;

Wang, FZ ;

Fegley, B ;

Chandran, B .

JOURNAL OF VIROLOGY, 2003, 77 (14) :7978-7990

[2] Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas [J].

An, J ;

Sun, Y ;

Fisher, M ;

Rettig, MB .

LEUKEMIA, 2004, 18 (10) :1699-1704

[3]

[Anonymous], 1997, IARC Monogr Eval Carcinog Risks Hum, V70, P1

[4] The EBV-Encoded dUTPase Activates NF-κB through the TLR2 and MyD88-Dependent Signaling Pathway [J].

Ariza, Maria-Eugenia ;

Glaser, Ronald ;

Kaumaya, Pravin T. P. ;

Jones, Chris ;

Williams, Marshall V. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :851-859

[5] Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-κB2 p100 to p52 [J].

Atkinson, PGP ;

Coope, HJ ;

Rowe, M ;

Ley, SC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) :51134-51142

[6] G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [J].

Bais, C ;

Santomasso, B ;

Coso, O ;

Arvanitakis, L ;

Raaka, EG ;

Gutkind, JS ;

Asch, AS ;

Cesarman, E ;

Gerhengorn, MC ;

Mesri, EA .

NATURE, 1998, 391 (6662) :86-89

[7] Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression [J].

Basseres, D. S. ;

Baldwin, A. S. .

ONCOGENE, 2006, 25 (51) :6817-6830

[8] The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase [J].

Beisser, PS ;

Verzijl, D ;

Gruijthuijsen, YK ;

Beuken, E ;

Smit, MJ ;

Leurs, R ;

Bruggeman, CA ;

Vink, C .

JOURNAL OF VIROLOGY, 2005, 79 (01) :441-449

[9]

Bélanger C, 2001, J HUMAN VIROL, V4, P62

[10] Activation of mitogen-activated protein kinase and NF-κB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein [J].

Brinkmann, MM ;

Glenn, M ;

Rainbow, L ;

Kieser, A ;

Henke-Gendo, C ;

Schulz, TF .

JOURNAL OF VIROLOGY, 2003, 77 (17) :9346-9358

← 1 2 3 4 5 6 7 8 9 →