NF-κB signaling modulation by EBV and KSHV

被引：109

作者：

de Oliveira, Deilson Elgui ^{[1
]}

Ballon, Gianna ^{[2
]}

Cesarman, Ethel ^{[2
]}

机构：

[1] Sao Paulo State Univ UNESP, Botucatu Sch Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil

[2] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA

来源：

TRENDS IN MICROBIOLOGY | 2010年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

EPSTEIN-BARR-VIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; PROTEIN-COUPLED RECEPTOR; PRIMARY-EFFUSION LYMPHOMA; GROWTH-FACTOR-RECEPTOR; ENDOTHELIAL-CELLS; LATENT MEMBRANE-PROTEIN-1; INDUCED APOPTOSIS; ACTIVATION; HUMAN-HERPESVIRUS-8;

D O I：

10.1016/j.tim.2010.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear factor (NF)-kappa B signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gamma-herpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappa B signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappa B modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.

引用

页码：248 / 257

页数：10

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