Diagnosis of prostatic intraepithelial neoplasia - Prostate Working Group 1 Consensus report

被引：26

作者：

Bostwick, DG

Montironi, R

Sesterhenn, IA

机构：

[1] Virginia Urol Ctr, Bostwick Labs, Richmond, VA 23294 USA

[2] NCI, Urol Oncol Div, Bethesda, MD 20892 USA

[3] Univ Virginia, Charlottesville, VA 22903 USA

[4] Univ Ancona, Sch Med, Dept Pathol, I-60128 Torrette Di Ancona, Italy

[5] Univ Hosp Lab, I-60128 Torrette Di Ancona, Italy

[6] Armed Forces Inst Pathol, Div Genitourinary Pathol, Washington, DC 20306 USA

来源：

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY | 2000年 / 34卷

关键词：

androgen ablation; atypical adenomatous hyperplasia; cancer; prostate; prostatic intraepithelial neoplasia; prostatic neoplasms; radiation therapy;

D O I：

10.1080/003655900750169266

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

High-grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not significantly elevate serum PSA concentration or its derivatives, nor does it induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention. Radiation therapy is also associated with a decreased incidence of PIN.

引用

页码：3 / 10

页数：8

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