Bergmann glia as putative stem cells of the mature cerebellum

被引：31

作者：

Alcock, Joelle ^{[1
]}

Scotting, Paul ^{[1
]}

Sottile, Virginie ^{[1
]}

机构：

[1] Univ Nottingham, Sch Med, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England

来源：

MEDICAL HYPOTHESES | 2007年 / 69卷 / 02期

关键词：

D O I：

10.1016/j.mehy.2007.01.006

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The adult brain is known to retain a population of stem cells with self-renewing and differentiation ability, which have been identified in two main regions. Recent reports now suggest the presence of such cells in the cerebellum, a part of the CNS which was not formerly thought to harbour stem cells. The precise nature and localisation of these potential new stem cells within the tissue remains unclear, as they have primarily been described at early postnatal stages, before completion of the extensive cell migration accompanying cerebellum maturation. We have shown that a discrete cell population of the cerebellar cortex, the Bergmann glia, shares the expression of key molecular markers with neural stem cells. We examine the hypothesis that the Bergmann glia may represent a novel and abundant stem cell population in the mature cerebellum. (c) 2007 Published by Elsevier Ltd.

引用

页码：341 / 345

页数：5

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