Unexpected rearrangement during biomimetic entry toward a taxane skeleton

被引：25

作者：

Nishizawa, M ^{[1
]}

Imagawa, H ^{[1
]}

Hyodo, I ^{[1
]}

Takeji, M ^{[1
]}

Morikuni, E ^{[1
]}

Asoh, K ^{[1
]}

Yamada, H ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708055, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 5-6期

关键词：

D O I：

10.1016/S0040-4039(97)10556-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bicyclol9.3.1]pentadecatriene derivative 4 which corresponds to a precursor of taxol in a biomimetic entry was constructed by means of TiCl4-Zn promoted McMurry cyclization and Mitsunobu inversion. Treatment of 4 with mercuric triflate afforded an unexpected rearrangement-transannular cyclization product 5. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：389 / 392

页数：4

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