Simulation of pore formation in lipid bilayers by mechanical stress and electric fields

被引：374

作者：

Tieleman, DP

Leontiadou, H

Mark, AE

Marrink, SJ

机构：

[1] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada

[2] Univ Groningen, Dept Biophys Chem, NL-9747 AG Groningen, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 21期

关键词：

D O I：

10.1021/ja029504i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe computer simulations of pore formation and membrane rupture of phospholipid bilayers under mechanical and electrical stress. On the nanosecond simulation time scale, pores are induced by a lateral pressure exceeding -200 bar or by an applied electric field of 0.5 V/nm. Copyright © 2003 American Chemical Society.

引用

页码：6382 / 6383

页数：2

共 13 条

[11] Voltage-dependent insertion of alamethicin at phospholipid/water and octane/water interfaces [J].