Synthesis and antimicrobial evaluation of TAN-1057A/B analogs

被引：24

作者：

Williams, RM ^{[1
]}

Yuan, CG

Lee, VJ

Chamberland, S

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

[2] Microcide Pharmaceut Co, Mountainview, CA 94043 USA

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 02期

关键词：

D O I：

10.7164/antibiotics.51.189

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

TAN-1057A similar to D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe, in detail, the synthesis of several TAN-1057A/B analogs by a convergent route featuring a new method to construct the cyclic amidinourea functional group. The biological activity of these substances against methicillin-resistant Staphylococcus aureus (MRSA) is reported.

引用

页码：189 / 201

页数：13

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