High-efficiency dialysis for carbamazepine overdose

被引：29

作者：

Schuerer, DJE ^{[1
]}

Brophy, PD ^{[1
]}

Maxvold, NJ ^{[1
]}

Kudelka, T ^{[1
]}

Bunchman, TE ^{[1
]}

机构：

[1] Univ Michigan, CS Mott Childrens Hosp, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 2000年 / 38卷 / 03期

关键词：

D O I：

10.1081/CLT-100100938

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Background: Carbamazepine intoxication is associated with seizures, coma, arrhythmias, and death, in acute! intoxications, charcoal hemoperfusion enhances removal of the drug but is associated with thrombocytopenia, coagulopathy, hypothermia, and hypocalcemia, Alternatively, high-efficiency hemodialysis can be used without the side effects of charcoal hemoperfusion, Case Report: We report an 18-month-old comatose, convulsing child with plasma carbamazepine 27 mu g/mL treated with high efficiency hemodialysis. Therapeutic carbamazepine levels were obtained after 3.5 hours of high-efficiency hemodialysis, The patient developed no untoward side effects, improved clinically, and was subsequently discharged home without sequelae, We conclude that high-efficiency hemodialysis is a safe, effective alternative to charcoal hemoperfusion in the pediatric population.

引用

页码：321 / 323

页数：3

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