An analysis of type-III secretion gene clusters in Chromobacterium violaceum

被引：22

作者：

Betts, HJ ^{[1
]}

Chaudhuri, RR ^{[1
]}

Pallen, MJ ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Inst Biomed Res, Div Immun & Infect,Bacterial Pathogenesis & Genom, Birmingham B15 2TT, W Midlands, England

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 11期

关键词：

D O I：

10.1016/j.tim.2004.09.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromobacterium violaceum is an environmental Gramnegative bacterium that is common in soil and water in tropical and sub-tropical regions. It is also a model organism for studying quorum-sensing and is a rare but deadly human pathogen. Recent completion of the genome sequence of C. violaceurn strain ATCC 12472 revealed the presence of genes associated with type-III secretion systems (TTSSs). One of these systems resembles the Spi-1 system found in Salmonella enterica, whereas another is similar to the Spi-2 system from the same organism. Here, we present a detailed analysis and a fresh annotation of the two gene clusters. Moreover, we highlight the presence of several genes encoding putative type-III effector proteins that lead us to predict that this organism can manipulate vesicular trafficking, the actin cytoskeleton and apoptotic pathways within mammalian cells to its own advantage.

引用

页码：476 / 482

页数：7

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