Axon growth inhibition: signals from the p75 neurotrophin receptor

被引：29

作者：

Kaplan, DR ^{[1
]}

Miller, FD ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Mol & Med Genet, Toronto, ON M5G 1X8, Canada

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 05期

关键词：

D O I：

10.1038/nn0503-435

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The Inhibition requires Interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that the Rho inhibitor Rho-GDIalpha mediates this signaling.

引用

页码：435 / 436

页数：2

共 15 条

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NATURE, 2002, 420 (6911) :74-78

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NATURE NEUROSCIENCE, 2002, 5 (12) :1302-1308

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[14] The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI [J].

Yamashita, T ;

Tohyama, M .

NATURE NEUROSCIENCE, 2003, 6 (05) :461-467

[15] The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho [J].

Yamashita, T ;

Higuchi, H ;

Tohyama, M .

JOURNAL OF CELL BIOLOGY, 2002, 157 (04) :565-570

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