The role of PI3K in immune cells

被引：412

作者：

Koyasu, S ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Microbiol & Immunol, Tokyo 1608582, Japan

[2] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi 3320012, Japan

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 04期

基金：

日本学术振兴会;

关键词：

D O I：

10.1038/ni0403-313

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of the phosphoinositide-3 kinase (PI3K) family control several cellular responses including cell growth, survival, cytoskeletal remodeling and the trafficking of intracellular organelles in many different types of cell. In particular PI3K has important functions in the immune system. It has been difficult to evaluate the roles of distinct PI3Ks in cellular immune responses because no PI3K inhibitors are specific for individual family members and because most stimuli activate several PI3K enzymes. The development of gene-targeted mice now enables us to examine the physiological functions of individual PI3K enzymes in the immune system in vivo.

引用

页码：313 / 319

页数：7

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