Mucosal HIV vaccines: A holy grail or a dud?

被引：28

作者：

Azizi, Ali ^{[1
,2
,3
]}

Ghunaim, Haitham ^{[1
,2
]}

Diaz-Mitoma, Francisco ^{[1
,2
,3
]}

Mestecky, Jiri ^{[4
]}

机构：

[1] Univ Ottawa, Dept Pathol & Lab Med, Ottawa, ON K1H 8M5, Canada

[2] Childrens Hosp Eastern Ontario, Res Inst, Infect Dis & Vaccine Res Ctr, Ottawa, ON K1H 8L1, Canada

[3] Variat Biotechnol Inc, Ottawa, ON K2G 3R8, Canada

[4] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

VACCINE | 2010年 / 28卷 / 24期

关键词：

HIV-1; Mucosal vaccines; Innate immune response; Tolerance; Adaptive immunity; HUMAN-IMMUNODEFICIENCY-VIRUS; TOXIN B-SUBUNIT; CD4(+) T-CELLS; SYSTEMIC IMMUNE-RESPONSES; NATURAL-KILLER-CELLS; CHOLERA-TOXIN; ALPHA-GALACTOSYLCERAMIDE; INTRANASAL IMMUNIZATION; ANTIBODY-RESPONSES; RHESUS MACAQUES;

D O I：

10.1016/j.vaccine.2010.04.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mucosal immune system appears to be a major target of the HIV infection. Therefore, a strong preexisting anti-HIV immune response in mucosal compartments might be able to prevent HIV infection. Conflicting views regarding the mechanisms of protection at mucosal sites, inferred by the contradictory results of mucosal vaccines in human clinical trials, attests to our lack of knowledge in understanding the human mucosal immune system. In this article, we briefly review the function of innate and adaptive immune responses and discuss current strategies and potential adjuvants in designing and delivering HIV vaccines through mucosal routes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4015 / 4026

页数：12

共 198 条

[1] Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice [J].

Akagi, T ;

Kawamura, M ;

Ueno, M ;

Hiraishi, K ;

Adachi, M ;

Serizawa, T ;

Akashi, M ;

Baba, M .

JOURNAL OF MEDICAL VIROLOGY, 2003, 69 (02) :163-172

[2]

[Anonymous], 2001, WKLY EPIDEMIOL REC, V76, P117

[3] Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques [J].

Azizi, Ali ;

Anderson, David E. ;

Torres, Jose V. ;

Ogrel, Andrei ;

Ghorbani, Masoud ;

Soare, Catalina ;

Sandstrom, Paul ;

Fournier, Jocelyne ;

Diaz-Mitoma, Francisco .

JOURNAL OF IMMUNOLOGY, 2008, 180 (04) :2174-2186

[4] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].

Baba, TW ;

Liska, V ;

Hofmann-Lehmann, R ;

Vlasak, J ;

Xu, WD ;

Ayehunie, S ;

Cavacini, LA ;

Posner, MR ;

Katinger, H ;

Stiegler, G ;

Bernacky, BJ ;

Rizvi, TA ;

Schmidt, R ;

Hill, LR ;

Keeling, ME ;

Lu, YC ;

Wright, JE ;

Chou, TC ;

Ruprecht, RM .

NATURE MEDICINE, 2000, 6 (02) :200-206

[5] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[6] Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope [J].

Barnetta, Susan W. ;

Srivastava, Indresh K. ;

Kan, Elaine ;

Zhou, Fengmin ;

Goodsell, Amanda ;

Cristillo, Anthony D. ;

Ferrai, Maria Grazia ;

Weiss, Deborah E. ;

Letvin, Norman L. ;

Montefiori, David ;

Pal, Ranajit ;

Vajdy, Michael .

AIDS, 2008, 22 (03) :339-348

[7] The HIV-1 matrix protein p 17 can be efficiently delivered by intranasal route in mice using the TLR 2/6 agonist MALP-2 as mucosal adjuvant [J].

Becker, Pablo D. ;

Fiorentini, Simona ;

Link, Claudia ;

Tosti, Giorgio ;

Ebensen, Thomas ;

Caruso, Arnaldo ;

Guzman, Carlos A. .

VACCINE, 2006, 24 (25) :5269-5276

[8] ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS IN VAGINAL SECRETIONS OF HETEROSEXUAL WOMEN [J].

BELEC, L ;

GEORGES, AJ ;

STEENMAN, G ;

MARTIN, PMV .

JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (03) :385-391

[9] Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge [J].

Belyakov, IM ;

Derby, MA ;

Ahlers, JD ;

Kelsall, BL ;

Earl, P ;

Moss, B ;

Strober, W ;

Berzofsky, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1709-1714

[10] Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina [J].

Bergquist, C ;

Johansson, EL ;

Lagergard, T ;

Holmgren, J ;

Rudin, A .

INFECTION AND IMMUNITY, 1997, 65 (07) :2676-2684

← 1 2 3 4 5 6 7 8 9 10 →