Mucosal HIV vaccines: A holy grail or a dud?

被引：28

作者：

Azizi, Ali ^{[1
,2
,3
]}

Ghunaim, Haitham ^{[1
,2
]}

Diaz-Mitoma, Francisco ^{[1
,2
,3
]}

Mestecky, Jiri ^{[4
]}

机构：

[1] Univ Ottawa, Dept Pathol & Lab Med, Ottawa, ON K1H 8M5, Canada

[2] Childrens Hosp Eastern Ontario, Res Inst, Infect Dis & Vaccine Res Ctr, Ottawa, ON K1H 8L1, Canada

[3] Variat Biotechnol Inc, Ottawa, ON K2G 3R8, Canada

[4] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

VACCINE | 2010年 / 28卷 / 24期

关键词：

HIV-1; Mucosal vaccines; Innate immune response; Tolerance; Adaptive immunity; HUMAN-IMMUNODEFICIENCY-VIRUS; TOXIN B-SUBUNIT; CD4(+) T-CELLS; SYSTEMIC IMMUNE-RESPONSES; NATURAL-KILLER-CELLS; CHOLERA-TOXIN; ALPHA-GALACTOSYLCERAMIDE; INTRANASAL IMMUNIZATION; ANTIBODY-RESPONSES; RHESUS MACAQUES;

D O I：

10.1016/j.vaccine.2010.04.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mucosal immune system appears to be a major target of the HIV infection. Therefore, a strong preexisting anti-HIV immune response in mucosal compartments might be able to prevent HIV infection. Conflicting views regarding the mechanisms of protection at mucosal sites, inferred by the contradictory results of mucosal vaccines in human clinical trials, attests to our lack of knowledge in understanding the human mucosal immune system. In this article, we briefly review the function of innate and adaptive immune responses and discuss current strategies and potential adjuvants in designing and delivering HIV vaccines through mucosal routes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4015 / 4026

页数：12

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