Junctophilins: A novel family of junctional membrane complex proteins

被引：541

作者：

Takeshima, H ^{[1
]}

Komazaki, S

Nishi, M

Lino, M

Kangawa, K

机构：

[1] Kurume Univ, Div Cell Biol, Inst Life Sci, Kurume, Fukuoka 8390861, Japan

[2] Univ Tokyo, Fac Med, Dept Pharmacol, Bunkyo Ku, Tokyo 1138654, Japan

[3] Japan Sci & Technol Corp, CREST, Bunkyo Ku, Tokyo 1138654, Japan

[4] Saitama Med Sch, Dept Anat, Moroyama, Saitama 3500495, Japan

[5] Natl Cardiovasc Ctr, Res Inst, Dept Biochem, Suita, Osaka 5658565, Japan

来源：

MOLECULAR CELL | 2000年 / 6卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(00)00003-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross-talk between cell surface and intracellular ion channels. We have identified the junctophilins (JPs), a novel conserved family of proteins that are components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. In mouse, there are at least three JP subtypes: JP-1, -2, and -3. JP-2 is abundantly expressed in the heart, and mutant mice lacking JP-2 exhibited embryonic lethality. Cardiac myocytes from the mutant mice showed deficiency of the junctional membrane complexes and abnormal Ca2+ transients. Our results suggest that JPs are important components of junctional membrane complexes.

引用

页码：11 / 22

页数：12