Synthesis of 9-amino-, 9-aminomethyl-1,2,3,4-tetrahydro- and 1,2,3,4,5,6,7,8-octahydroacridine derivatives

被引：8

作者：

Del Giudice, MR ^{[1
]}

Borioni, A ^{[1
]}

Mustazza, C ^{[1
]}

Gatta, F ^{[1
]}

机构：

[1] Ist Super Sanita, Lab Chim Farm, I-00161 Rome, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 06期

关键词：

D O I：

10.1002/jhet.5570340604

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes the synthesis of 9-amino-2- and 4-hydroxy- and 2,4-dihydroxy-1,2,3,4-tetrahydroacridines 2 and of 9-aminomethyl-1,2,3,4-tetrahydro- and 1,2,3,4,5,6,7,8-octahydroacridines 3 starting from the corresponding 9-carboxamido derivatives. A new synthetical pathway to 9-amino-2-hydroxyacridine 9 is also reported.

引用

页码：1661 / 1667

页数：7

共 11 条

[1] ANALOGS OF 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE [J].

BIELAVSKY, J .

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1977, 42 (09) :2802-2808

[2]

delGiudice MR, 1996, FARMACO, V51, P693

[3]

EAGGER SA, 1991, LANCET, V337, P889

[4] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[5] Synthesis of 10-amino-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridines and related derivatives [J].

Gatta, F ;

DelGiudice, MR ;

Mustazza, C .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (06) :1807-1813

[6]

HSU RS, 1990, DRUG METAB DISPOS, V18, P779

[7]

JOHN V, 1993, ANNU REP MED CHEM, V28, P197

[8]

KUMAR V, 1991, INT J CLIN PHARM TH, V29, P23

[9] SELECTIVE HYDROGENATION OF 9-AMINOACRIDINE OVER SUPPORTED NOBLE-METAL CATALYSTS [J].

SAKANISHI, K ;

MOCHIDA, I ;

OKAZAKI, H ;

SOEDA, M .

CHEMISTRY LETTERS, 1990, (02) :319-322

[10] Frameshift mutagenicity and DNA intercalation of 9-amino-2-hydroxyacridine, a rat liver S9 metabolite of 9-aminoacridine [J].

Tomosaka, H ;

Anzai, K ;

Hasegawa, E ;

Horigome, T ;

Omata, S .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (04) :714-716

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